Crossover collaborates with a network of healthcare institutions to identify and recruit patients into clinical trials via dedicated clinical research units which it establishes, staffs and manages.
Crossover CRI AG (Crossover) runs a network of Clinical Research Units (CRUs) in partnership with research-driven healthcare institutions. Our CRUs are located on-site at the healthcare institutions and have professional and dedicated Crossover staff managing the entire portfolio of clinical trials at the institutions they serve. The key roles of the CRUs are to train research teams within the healthcare institutions on good clinical practice (GCP), regulatory guidelines and protocol-specific needs, to enable them to manage the projects, support investigative teams and conduct in-process quality control. Crossover provides on-site administrative resources for the investigators and also manages the clinical trial dataflow, either paper-based or electronic.
Crossover has developed a
clinical trials database
for its partner hospitals
and investigators … more
Nathalie Vandenhoudt, PhD,
Clinical Study Coordinator
at the Crossover Clinical
Research Unit in Brussels … more
Crossover observes a
continuing decline in
industry-sponsored clinical
trials. Since … more
Healthcare institutions
To the healthcare institutions in the Crossover Clinical Research Infrastructures Network (COCRIN), Crossover brings a wealth of expertise and best practices in running clinical trials and meeting the international standards demanded by sponsors and regulatory authorities, as well as financing the CRUs, staff and equipment. The healthcare institutions in the Crossover network can carry out more studies and thereby offer more innovative diagnostic and therapeutic options to more patients than institutions which do not have this dedicated support.
Most if not all academic kamagra and teaching hospitals are involved in various national and international medical and scientific networks, for example by medical specialty, disease, medical technology or type of healthcare institution. The Crossover model is highly complementary to these networks. Crossover’s Clinical Research Units at hospitals in various countries enable these to implement the Clinical Trials they want to pursue, whether commercial or non-commercial. Thus, Crossover’s COCRIN is an operational infrastructure providing Clinical Trial support and standardised procedures, whereas the medical and scientific networks focus on the content of research programs. The Crossover model should increase the chances of hospitals and their investigators to be selected for accommodating research activities sponsored by medical and scientific networks.
The following are the COCRIN membership options for your Healthcare Institution:
You become a COCRIN Partner, maintain your own existing institutional CRU, and receive the Crossover SOPs, training and annual audits. Crossover markets COCRIN worldwide to sponsors and brings clinical trials to its Partners;
You become a COCRIN Supported Partner by establishing your own institutional CRU, and receiving all of the above, plus initial and ongoing management support;
You become a COCRIN Co-Development Partner by establishing a Crossover CRU, and receiving all of the above, plus Crossover will equip and staff the CRU – including CRF data entry – at its cost, where you provide the space;
You become a COCRIN Full-Development Partner by establishing a Crossover CRU, and receiving all of the above, plus Crossover will provide the office for the CRU on your campus;
If your Institution already has an institutional CRU, you may want to discuss a transfer to Crossover.
If your Healthcare Institution is interested in one of the COCRIN partnering options, please click on Registration in the left menu and fill out the questionnaire.
Investigators
For investigators at healthcare institutions with a Crossover CRU, we provide a significant reduction in the administrative and logistical challenges of clinical trials. The CRUs’ mission is to support the kamagra 100mg principal investigators and their staff in every possible way by lightening the load of work not directly related to patient care and scientific observations.
If you are interested in receiving clinical trials from Crossover, please register by filling out a questionnaire which you will find by clicking on Registration in the left menu.
Sponsors and clinical CROs
To sponsors and CROs, the COCRIN solution offers an enhanced process for conducting clinical trials with comprehensive project management leading to improved quality of research data. Our on-site CRU model offers greater responsiveness to the administrative, logistical, connectivity and other operational needs of sponsors and CROs. Highly trained and certified staff at the healthcare institutions in our network and in-process quality control significantly reduce the sponsor requirement for external monitoring and associated travel.
Hospital information systems
In parallel, Crossover accesses data from the hospital information systems (HIS) of healthcare institutions in the network – subject to patient confidentiality, data privacy and Ethics Committee approvals – to support feasibility, clinical trial data processing and investigative secondary research activities.
About us
The Crossover clinical research model
Crossover CRI AG (Crossover) is currently establishing a large international network of Clinical Research Units (CRUs) in research-driven healthcare institutions. Our CRUs are located on-site at the healthcare institution to enable the collection and analysis of healthcare information both in clinical trials and epidemiology studies.
Crossover invests in establishing and staffing the CRUs that are responsible for conducting all clinical trials carried out at the selected healthcare institutions which are kamagra bruistabletten kopen part of the Crossover network. Over the next 10 years, it is expected that this network will expand to include more than 175 healthcare institutions in all parts of the world.
In parallel, Crossover establishes access to the hospital information systems (HIS) of healthcare institutions within the network, populating on a continuous basis the Epidemiology Database (EPIDAB) and warehousing de-identified electronic medical record/electronic health record patient data.
Crossover improves the feasibility of clinical trials and provides population studies of better quality and at a more affordable cost than healthcare institutions without a dedicated CRU. Its epidemiology database (EPIDAB) is used for data mining to support a wide range of medical, scientific and market research needs (interventional and non-interventional clinical trials, non-applied clinical research and market research) of significant interest to pharmaceutical companies, academic researchers, CROs and healthcare planners, providers and insurers.
Crossover offers a new and unique model for kamagra gel belgië clinical research and epidemiology. The advantages over previous models are:
Lower costs through proximity with medical technology clusters and the use of academic and healthcare institution staff peripherally on an ad hoc basis rather than central staff
Closer cooperation with sponsors through the distribution of project managers at healthcare institutions in close vicinity of sponsor clusters
Bridging the gap between healthcare databases and clinical trial databases through the standardisation of work practice and use of internationally recognised coding systems and nomenclature, the continuous development of sophisticated data collection and validation systems in healthcare practice and clinical research, intensive training of staff at research sites and the use of advanced integrated IT systems
Objective feasibility studies, faster project turnaround and higher quality
Healthcare data
Hospital Information Systems
Crossover provides generic and customised solutions to enable access to healthcare and administrative data that are stored in the hospital information systems (HIS) for the institutions belonging to the Crossover network. Data access is strictly controlled and subject to the relevant data privacy laws and regulations in kamagra jelly kopen force at each institution. Crossover uses HIS data in three different ways:
- to screen for eligible patients and project future trends based on protocol inclusion and exclusion criteria
- to create repositories of HIS data that may be used either directly or indirectly to automate clinical trial data processing and hence enhance trial performance and improve data quality
- to create a world class secondary (epidemiological) research database by combining suitably anonymised HIS data from the many institutions that belong to the Crossover network.
Electronic data capture systems (EDC systems)
Crossover provides expertise and technical solutions to enable the integration of sponsor EDC and other automated data capture systems at healthcare institutions and in the Crossover clinical research units (CRUs) which it operates. In addition Crossover CRU and technical staff are available to work directly with sponsors to train and support investigators and other site staff regarding data, telecommunication and infrastructure solutions. The scope of this activity includes:
- electronic CRF data
- electronic device data, e.g., spirometry
- PRO and ePRO kamagra kauwtabletten data
- laboratory data
- imaging data
Feasibility
Crossover has exclusive access to medical data for patients treated at healthcare institutions that belong to its network. In addition, Crossover employs staff who are experts in the structure and management of several different hospital information systems, and has developed a methodology and an automated approach to enable the rapid identification of patients who meet protocol entry criteria. The system can also handle scenario analysis, for example based on variations to the original protocol to allow sponsors to easily and efficiently identify expected patient numbers based on alternative combinations of entry criteria.
Clinical trials
Much of the data held in the HIS is the same as that which is required for clinical trial purposes. In recent years, research has intensified to develop solutions that will integrate HIS and clinical research needs. For each institution in the Crossover network, the “pocket” of data held in HIS that is also needed for clinical research purposes (both feasibility and clinical trials) has been defined and is held separately in a set of “mirror” tables within the HIS system. These “mirror” tables are encoded, where appropriate, using the standard coding systems in use for clinical research and regulatory approval purposes – namely CDISC, HL7, MedDRA.
Secondary research
Crossover has an agreement with the institutions belonging to the Crossover network to create anonymised datasets from the HIS that can be exported, consolidated and held in a kamagra oral jelly data warehouse for secondary processing and exploratory research purposes. The data warehouse includes referral and patient information, results from laboratory tests and other procedures as well as interventions and prescription information. The data warehouse is structured for analysis and reporting purposes and uses standard coding nomenclature to enable data to be easily merged with information from similarly structured research databases. Crossover employs statisticians, epidemiologists and market researchers to answer key questions of scientific, medical and commercial interest.